Epilepsy and mood disorders

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Mood disorders in patients with epilepsy.

Epilepsy is a common disabling neurological disorder associated with increased rates of mood disorders especially depression as compared to the general population. Most antidepressants at therapeutic dosages exhibit a seizure risk. Some antidepressants may also display antiepileptic effects, especially at low doses, but the mechanism of this action is largely unknown. In general, the new antide...

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Mood disorders in epilepsy - diagnostic and methodological considerations.

BACKGROUND Mood disorders are common in people with epilepsy (PWE) with prevalence rates ranging from 11% to 62%. The variation in epidemiological data results probably from the diversity of methodologies employed and selection of the populations across the studies. Moreover, the symptomathology of mood disorders in epilepsy is often atypical, intermittent and pleomorphic and fails to meet DSM-...

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Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy.

BACKGROUND Mood disorders have been described as the commonest psychiatric disorders in patients with temporal lobe epilepsy. Secondary depression in temporal lobe epilepsy could be interpreted either as an adjustment reaction to a chronic disease or as a limbic dysfunction. To clarify this issue, a controlled study of psychiatric disorders was conducted in different forms of epileptic and non-...

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Pathophysiology of mood disorders in temporal lobe epilepsy.

OBJECTIVE There is accumulating evidence that the limbic system is pathologically involved in cases of psychiatric comorbidities in temporal lobe epilepsy (TLE) patients. Our objective was to develop a conceptual framework describing how neuropathological, neurochemical and electrophysiological aspects might contribute to the development of psychiatric symptoms in TLE and the putative neurobiol...

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MOOD DISORDERS AND MEDICAL ILLNESS Mood Disorders and Allostatic Load

The brain controls both the physiologic and the behavioral coping responses to daily events as well as major stressors, and the nervous system is itself a target of the mediators of those responses through circulating hormones. The amygdala and hippocampus interpret what is stressful and regulate appropriate responses. The amygdala becomes hyperactive in posttraumatic stress disorder (PTSD) and...

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ژورنال

عنوان ژورنال: Epilepsia

سال: 2007

ISSN: 0013-9580

DOI: 10.1111/j.1528-1167.2007.01395.x